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Our research focuses on venous thromboembolic disease, as well as risk factors of atherosclerosis and cardiovascular complications of rheumatic diseases. We are also interested in the cardiovascular complications associated with renal impairment and hepatic insufficiency. We initiated and coordinated RiHTER, coordinated in Poland PEITHO trial , currently we participate in academic trials ISCHEMIA and InShape-2.

PEITHO The Pulmonary Embolism International Thrombolysis Study (PEITHO) was a large international, randomized, double-blind, placebo-controled, investigator initiated and academically sponsored trial, which set out to determine whether normotensive, intermediate-risk patients with confirmed pulmonary embolism (PE) and right ventricular dysfunction, plus laboratory markers of myocardial injury may benefit from early thrombolytic treatment with tenecteplase.


Right Heart Thrombi European Registry an investigator initiated multicenter, international registry. RIHTER has been organized in order to assess the prognostic significance of RiHT characteristics according to their size and mobility, especially in relation to the established prognostic factors for 30-day mortality: haemodynamic instability, right ventricular dysfunction, simplified Pulmonary Embolism Severity Index, and laboratory markers of myocardial injury and overload. Moreover, we assessed the potential prognostic value of RiHT and their potential influence on treatment selection in comparison with propensity score-matched pulmonary embolism patients contemporarily managed in the centres participating in the registry.

ISCHEMIA - an NHLBI-funded international randomized controlled trial comparing the effectiveness of two initial management strategies in 5,000 to 6,000 patients with at least moderate ischemia on stress testing: an invasive strategy with cardiac catheterization and optimal revascularization plus OMT versus a conservative strategy with OMT alone and cath reserved for patients who fail medical therapy.

InShape-2 study Early non-invasive detection of CTEPH after pulmonary embolism – The InShape-2 study. The primary objective of the study is to evaluate the diagnostic accuracy of a CTEPH screening program based on the stratification score and the ‘rule out criteria.

We are also involved in other clinical studies focused on the management of acute pulmonary embolism, heart failure, and arrhythmia.

Selected 40 scientific publications (2010-2016):

  1. Marek Roik, Dominik Wretowski, Maciej Kostrubiec, Olga Dzikowska-Diduch, Andrzej Łabyk, Katarzyna Irzyk, Barbara Lichodziejewska, Anna Wyzgał, Krzysztof Jankowski, Piotr Pruszczyk High prevalence of severe coronary artery disease in elderly patients with non-operable chronić thromboembolic pulmonary hypertension referred for balloon pulmonary angioplasty. Adv Interv Cardiol 2016 Dec; 12, 4 (46): 355–359

  2. Roik M, Wretowski D, Labyk A, Kostrubiec M, Irzyk K, Dzikowska-Diduch O, Lichodziejewska B, Ciurzynski M, Kurnicka K, Golebiowski M, Pruszczyk P. Refined balloon pulmonary angioplasty driven by combined assessment of intra-arterial anatomy and physiology--Multimodal approach to treated lesions in patients with non-operable distal chronic thromboembolic pulmonary hypertension--Technique, safety and efficacy of 50 consecutive angioplasties. Int J Cardiol. 2016 Jan 15;203:228-35.

  3. Kurnicka K, Lichodziejewska B, Goliszek S, Dzikowska-Diduch O, Zdonczyk O, Kozlowska M, Kostrubiec M, Ciurzynski M, Palczewski P, Grudzka K, Krupa M, Koc M, Pruszczyk P. Echocardiographic Pattern of Acute Pulmonary Embolism: Analysis of 511 Consecutive Patients. J Am Soc Echocardiogr. 2016 Sep;29(9):907-13.

  4. Koc M, Kostrubiec M, Elikowski W, Meneveau N, Lankeit M, Grifoni S, Kuch-Wocial A, Petris A, Zaborska B, Stefanovic BS, Hugues T, Torbicki A, Konstantinides S, Pruszczyk P, Ri HI. Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry. Eur Respir J. 2016 Mar;47(3):869-75.

  5. Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. J Thromb Haemost. 2016 Jan;14(1):121-8.

  6. Wyzgal A, Koc M, Pacho S, Bielecki M, Wawrzyniak R, Kostrubiec M, Ciurzynski M, Kurnicka K, Goliszek S, Paczynska M, Palczewski P, Pruszczyk P. Plasma copeptin for short term risk stratification in acute pulmonary embolism. J Thromb Thrombolysis. 2016 May;41(4):563-8.

  7. Bienias P, Lusakowska A, Ciurzynski M, Rymarczyk Z, Irzyk K, Kurnicka K, Kaminska A, Pruszczyk P. Supraventricular and Ventricular Arrhythmias Are Related to the Type of Myotonic Dystrophy but Not to Disease Duration or Neurological Status. Pacing Clin Electrophysiol. 2016 Sep;39(9):959-68.

  8. Becattini C, Agnelli G, Lankeit M, Masotti L, Pruszczyk P, Casazza F, Vanni S, Nitti C, Kamphuisen P, Vedovati MC, De Natale MG, Konstantinides S. Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. Eur Respir J. 2016 Sep;48(3):780-6.

  9. Kukla P, McIntyre WF, Koracevic G, Kutlesic-Kurtovic D, Fijorek K, Atanaskovic V, Krupa E, Mirek-Bryniarska E, Jastrzebski M, Bryniarski L, Pruszczyk P, Baranchuk A. Relation of atrial fibrillation and right-sided cardiac thrombus to outcomes in patients with acute pulmonary embolism. Am J Cardiol. 2015 Mar 15;115(6):825-30.

  10. Kostera-Pruszczyk A, Suszek M, Ploski R, Franaszczyk M, Potulska-Chromik A, Pruszczyk P, Sadurska E, Karolczak J, Kaminska AM, Redowicz MJ. BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome. J Muscle Res Cell Motil. 2015 Dec;36(6):423-32.

  11. Kostera-Pruszczyk A, Potulska-Chromik A, Pruszczyk P, Bieganowska K, Miszczak-Knecht M, Bienias P, Szczaluba K, Lee HY, Quinn E, Ploski R, Kaminska A, Ptacek LJ. Andersen-Tawil syndrome: report of 3 novel mutations and high risk of symptomatic cardiac involvement. Muscle Nerve. 2015 Feb;51(2):192-6.

  12. Kaeberich A, Seeber V, Jimenez D, Kostrubiec M, Dellas C, Hasenfuss G, Giannitsis E, Pruszczyk P, Konstantinides S, Lankeit M. Age-adjusted high-sensitivity troponin T cut-off value for risk stratification of pulmonary embolism. Eur Respir J. 2015 May;45(5):1323-31.

  13. Irzyk K, Bienias P, Rymarczyk Z, Bartoszewicz Z, Siwicka M, Bielecki M, Karpinska A, Dudzik-Niewiadomska I, Pruszczyk P, Ciurzynski M. Assessment of systemic and pulmonary arterial remodelling in women with systemic sclerosis. Scand J Rheumatol. 2015;44(5):385-8.

  14. Gaciong Z, Pruszczyk P, Religa P. Cancer Screening in Unprovoked Venous Thromboembolism. N Engl J Med. 2015 Dec 17;373(25):2474-5.

  15. Domienik-Karlowicz J, Rymarczyk Z, Dzikowska-Diduch O, Lisik W, Chmura A, Demkow U, Pruszczyk P. Emerging markers of atherosclerosis before and after bariatric surgery. Obes Surg. 2015 Mar;25(3):486-93.

  16. Digby GC, Kukla P, Zhan ZQ, Pastore CA, Piotrowicz R, Schapachnik E, Zareba W, Bayes de Luna A, Pruszczyk P, Baranchuk AM. The value of electrocardiographic abnormalities in the prognosis of pulmonary embolism: a consensus paper. Ann Noninvasive Electrocardiol. 2015 May;20(3):207-23.

  17. Bienias P, Kostrubiec M, Rymarczyk Z, Korczak D, Ciurzynski M, Kurzyna M, Torbicki A, Fijalkowska A, Pruszczyk P. Severity of arterial and chronic thromboembolic pulmonary hypertension is associated with impairment of heart rate turbulence. Ann Noninvasive Electrocardiol. 2015 Jan;20(1):69-78.

  18. Bienias P, Ciurzynski M, Kostrubiec M, Rymarczyk Z, Kurzyna M, Korczak D, Roik M, Torbicki A, Fijalkowska A, Pruszczyk P. Functional class and type of pulmonary hypertension determinate severity of cardiac autonomic dysfunction assessed by heart rate variability and turbulence. Acta Cardiol. 2015 Jun;70(3):286-96.

  19. Roik M, Wretowski D, Wolny R, Labyk A, Kostrubiec M, Pruszczyk P. StentBoost imaging for the assessment of optimal stent deployment and coverage of side branch ostium in coronary bifurcation intervention. Int J Cardiol. 2014 Apr 1;172(3):e458-60.

  20. Roik M, Wretowski D, Rowinski O, Labyk A, Kostrubiec M, Lichodziejewska B, Irzyk K, Dzikowska-Diduch O, Zybinska S, Szramowska A, Pruszczyk P. Refined balloon pulmonary angioplasty in inoperable chronic thromboembolic pulmonary hypertension--a multi-modality approach to the treated lesion. Int J Cardiol. 2014 Dec 20;177(3):e139-41.

  21. Roik M, Wretowski D, Labyk A, Kostrubiec M, Rowinski O, Pruszczyk P. Optical coherence tomography imaging of inoperable chronic thromboembolic pulmonary hypertension treated with refined balloon pulmonary angioplasty. Pol Arch Med Wewn. 2014 Oct 30.

  22. Pruszczyk P, Goliszek S, Lichodziejewska B, Kostrubiec M, Ciurzynski M, Kurnicka K, Dzikowska-Diduch O, Palczewski P, Wyzgal A. Prognostic value of echocardiography in normotensive patients with acute pulmonary embolism. JACC Cardiovasc Imaging. 2014 Jun;7(6):553-60.

  23. Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galie N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV, Investigators P. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014 Apr 10;370(15):1402-11.

  24. Lankeit M, Jimenez D, Kostrubiec M, Dellas C, Kuhnert K, Hasenfuss G, Pruszczyk P, Konstantinides S. Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk stratification of pulmonary embolism. Eur Respir J. 2014 Jun;43(6):1669-77.

  25. Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galie N, Gibbs JS, Huisman MV, Humbert M, Kucher N, Lang I, Lankeit M, Lekakis J, Maack C, Mayer E, Meneveau N, Perrier A, Pruszczyk P, Rasmussen LH, Schindler TH, Svitil P, Vonk Noordegraaf A, Zamorano JL, Zompatori M, Task Force for the D, Management of Acute Pulmonary Embolism of the European Society of C. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014 Nov 14;35(43):3033-69, 69a-69k.

  26. Gromadzinski L, Pruszczyk P. Echocardiographic changes in patients with stage 3-5 chronic kidney disease and left ventricular diastolic dysfunction. Cardiorenal Med. 2014 Dec;4(3-4):234-43.

  27. Goliszek S, Wisniewska M, Kurnicka K, Lichodziejewska B, Ciurzynski M, Kostrubiec M, Golebiowski M, Babiuch M, Paczynska M, Koc M, Palczewski P, Wyzgal A, Pruszczyk P. Patent foramen ovale increases the risk of acute ischemic stroke in patients with acute pulmonary embolism leading to right ventricular dysfunction. Thromb Res. 2014 Nov;134(5):1052-6.

  28. Pedowska-Wloszek J, Kostrubiec M, Kurnicka K, Ciurzynski M, Palczewski P, Pruszczyk P. Midregional proadrenomedullin (MR-proADM) in the risk stratification of patients with acute pulmonary embolism. Thromb Res. 2013 Nov;132(5):506-10.

  29. Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, Casazza F, Salvi A, Grifoni S, Carugati A, Konstantinides S, Schreuder M, Golebiowski M, Duranti M. Multidetector CT scan for acute pulmonary embolism: embolic burden and clinical outcome. Chest. 2012 Dec;142(6):1417-24.

  30. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Pacho S, Dzikowska-Diduch O, Dul P, Ciurzynski M, Bienias P, Pruszczyk P. Rapid improvement of renal function in patients with acute pulmonary embolism indicates favorable short term prognosis. Thromb Res. 2012 Sep;130(3):e37-42.

  31. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Dzikowska-Diduch O, Wojciechowski A, Garlinska M, Ciurzynski M, Pruszczyk P. Neutrophil gelatinase-associated lipocalin, cystatin C and eGFR indicate acute kidney injury and predict prognosis of patients with acute pulmonary embolism. Heart. 2012 Aug;98(16):1221-8.

  32. Lankeit M, Jimenez D, Kostrubiec M, Dellas C, Hasenfuss G, Pruszczyk P, Konstantinides S. Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study. Circulation. 2011 Dec 13;124(24):2716-24.

  33. Gromadzinski L, Ciurzynski M, Januszko-Giergielewicz B, Targonski R, Cyganski P, Pruszczyk P. Diagnostic value of mitral and tricuspid annular excursion in the diagnostics of acute pulmonary embolism patients with chronic heart failure. Int J Cardiol. 2011 May 19;149(1):118-9.

  34. Domienik-Karlowicz J, Lichodziejewska B, Lisik W, Ciurzynski M, Bienias P, Chmura A, Pruszczyk P. Electrocardiographic criteria of left ventricular hypertrophy in patients with morbid obesity. Ann Noninvasive Electrocardiol. 2011 Jul;16(3):258-62.

  35. Becattini C, Agnelli G, Vedovati MC, Pruszczyk P, Casazza F, Grifoni S, Salvi A, Bianchi M, Douma R, Konstantinides S, Lankeit M, Duranti M. Multidetector computed tomography for acute pulmonary embolism: diagnosis and risk stratification in a single test. Eur Heart J. 2011 Jul;32(13):1657-63.

  36. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Pacho S, Wojciechowski A, Jankowski K, Ciurzynski M, Pruszczyk P. Assessment of renal dysfunction improves troponin-based short-term prognosis in patients with acute symptomatic pulmonary embolism. J Thromb Haemost. 2010 Apr;8(4):651-8.

  37. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Hrynkiewicz-Szymanska A, Pacho S, Jankowski K, Lichodziejewska B, Pruszczyk P. Mean platelet volume predicts early death in acute pulmonary embolism. Heart. 2010 Mar;96(6):460-5.

  38. Jankowski K, Kostrubiec M, Ozdowska P, Milanowska-Puncewicz B, Pacho S, Pedowska-Wloszek J, Kaczynska A, Labyk A, Hrynkiewicz A, Pruszczyk P. Electrocardiographic differentiation between acute pulmonary embolism and non-ST elevation acute coronary syndromes at the bedside. Ann Noninvasive Electrocardiol. 2010 Apr;15(2):145-50.

  39. Bienias P, Ciurzynski M, Korczak D, Jankowski K, Glinska-Wielochowska M, Liszewska-Pfejfer D, Glinski W, Pruszczyk P. Pulmonary hypertension in systemic sclerosis determines cardiac autonomic dysfunction assessed by heart rate turbulence. Int J Cardiol. 2010 Jun 11;141(3):322-5.

  40. Bienias P, Ciurzynski M, Glinska-Wielochowska M, Korczak D, Kalinska-Bienias A, Glinski W, Pruszczyk P. Heart rate turbulence impairment and ventricular arrhythmias in patients with systemic sclerosis. Pacing Clin Electrophysiol. 2010 Aug;33(8):920-8.